Today's Seventeen Second Spark focusses on Shopify Shipping using multiple locations. Shipping rates are calculated based on the address of your store's shipping origin location, not the fulfillment location for each order. This means that all your locations share the same shipping zone.
If you offer free shipping or flat-rate shipping for all your orders, then you don't need to change your shipping settings.
If your shipping rates vary significantly between locations, then you can change the location that is set as your shipping origin.